Congratulations to Sophia Park for discovering SUMO-modification on GBL, a core regulator of mTOR kinase pathway.

Sophia's research has demonstrated that GBL can undergo post-translational modifications at several lysine residues by SUMO, a tiny ubiquitin-like modifier. This alteration changes GBL's interaction with its primary interactor, the mammalian target of rapamycin (mTOR) kinase, and enhances mTOR activity in substrate phosphorylation. PMC10982569